Sofosvel (Sofosbuvir and Velpatasvir)
What is Sofosvel (Generic Sofosbuvir and Velpatasvir)?
Sofosvel (Generic Sofosbuvir and Velpatasvir) contains a combination of sofosbuvir and velpatasvir. Sofosbuvir and velpatasvir are antiviral medications that prevent hepatitis C virus (HCV) from multiplying in your body. Sofosvel (Generic Sofosbuvir and Velpatasvir) is used to treat chronic hepatitis C in adults with HCV genotype 1, 2, 3, 4, 5, or 6. Sofosvel (Generic Sofosbuvir and Velpatasvir) is given in combination with another antiviral medicine called ribavirin in people who also have advanced cirrhosis.
Sofosvel (Generic Sofosbuvir and Velpatasvir) is sometimes used in combination with ribavirin. Ribavirin can cause birth defects or death in an unborn baby. Do not use ribavirin if you are pregnant, or if you are a man and your sexual partner is pregnant. Use effective birth control to prevent pregnancy while using Sofosvel (Generic Sofosbuvir and Velpatasvir) and ribavirin together and for at least 6 months after treatment ends. Read the medication guide or patient instructions provided with each medication in your combination therapy. Do not change your doses or medication schedule without your doctor's advice.
Before taking this medicine
You should not use Sofosvel (Generic Sofosbuvir and Velpatasvir) if you are allergic to sofosbuvir or velpatasvir. To make sure Sofosvel (Generic Sofosbuvir and Velpatasvir) is safe for you, tell your doctor if you have: kidney disease (or if you are on dialysis); liver problems other than hepatitis C; HIV (human immunodeficiency virus); or if you have recently used a heart rhythm medicine called amiodarone (Cordarone, Pacerone). It is not known whether Sofosvel (Generic Sofosbuvir and Velpatasvir) will harm an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant. Sofosvel (Generic Sofosbuvir and Velpatasvir) is sometimes used in combination with ribavirin. Ribavirin can cause birth defects or death in an unborn baby. You may need to have a negative pregnancy test before using these medications together, and every month during your treatment. If you are a woman, do not use Sofosvel (Generic Sofosbuvir and Velpatasvir) with ribavirin if you are pregnant. If you are a man, do not use this drug combination if your sexual partner is pregnant. An unborn baby could also be harmed if a man fathers the child while he is taking ribavirin. Use effective birth control to prevent pregnancy while either sexual partner is using these medications together. Keep using this birth control for at least 6 months after treatment ends. Tell your doctor right away if a pregnancy occurs while either the mother or the father is using Sofosvel (Generic Sofosbuvir and Velpatasvir) with ribavirin. It is not known whether sofosbuvir and velpatasvir passes into breast milk or if it could harm a nursing baby. You should not breast-feed while using this medicine.
How should I take Sofosvel (Generic Sofosbuvir and Velpatasvir)?
Sofosvel (Generic Sofosbuvir and Velpatasvir) is usually taken once per day for 12 weeks. Follow all directions on your prescription label. Do not take this medicine in larger or smaller amounts or for longer than recommended. You may take Sofosvel (Generic Sofosbuvir and Velpatasvir) with or without food. Read the medication guide or patient instructions provided with each medication you take. Do not change your doses or medication schedule without your doctor's advice. Every person with hepatitis C should remain under the care of a doctor. While using Sofosvel (Generic Sofosbuvir and Velpatasvir), you may need frequent blood tests. Store this medicine in the original container at room temperature away from moisture and heat.
Sofosvel (Generic Sofosbuvir and Velpatasvir) dosing information
Usual Adult Dose of Sofosvel (Generic Sofosbuvir and Velpatasvir) for Chronic Hepatitis C: 1 tablet orally once a day, Regimen and Duration of Therapy: -Patients without cirrhosis and patients with compensated cirrhosis (Child-Pugh A): Sofosbuvir-velpatasvir for 12 weeks -Patients with decompensated cirrhosis (Child-Pugh B or C): Sofosbuvir-velpatasvir and ribavirin for 12 weeks
-If applicable, the manufacturer product information for ribavirin should be consulted regarding dosing (including dose adjustments).
Uses: For the treatment of chronic HCV genotype 1, 2, 3, 4, 5, or 6 infection, -In patients without cirrhosis or with compensated cirrhosis, -In combination with ribavirin: In patients with decompensated cirrhosis
What happens if I miss a dose?
Take the missed dose as soon as you remember. Skip the missed dose if it is almost time for your next scheduled dose. Do not take extra medicine to make up the missed dose.
What happens if I overdose?
Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.
What should I avoid while taking Sofosvel (Generic Sofosbuvir and Velpatasvir)?
If you also take omeprazole (Prilosec), do not take it for at least 4 hours after you have taken your dose of Sofosvel (Generic Sofosbuvir and Velpatasvir) (with food). Taking this medication will not prevent you from passing hepatitis C to other people. Do not have unprotected sex or share razors or toothbrushes. Talk with your doctor about safe ways to prevent HCV transmission during sex. Sharing drug or medicine needles is never safe, even for a healthy person.
Sofosvel (Generic Sofosbuvir and Velpatasvir) side effects
Get emergency medical help if you have signs of an allergic reaction to Sofosvel (Generic Sofosbuvir and Velpatasvir): hives; difficult breathing; swelling of your face, lips, tongue, or throat. Call your doctor at once if you have: slow heartbeats; weak or shallow breathing; or low red blood cells-pale skin, weakness, rapid heart rate, trouble concentrating. If you also take amiodarone: Seek medical help right away if you feel weak, tired, or light-headed, or if you have chest pain, shortness of breath, confusion, or memory problems. Common Sofosvel (Generic Sofosbuvir and Velpatasvir) side effects may include: headache; tired feeling; nausea, diarrhea; or sleep problems (insomnia).
What other drugs will affect Sofosvel (Generic Sofosbuvir and Velpatasvir)?
Many drugs can interact with sofosbuvir and velpatasvir. Not all possible interactions are listed here. Tell your doctor about all your current medicines and any you start or stop using, especially: amiodarone; digoxin; St. John's wort; topotecan; any medicine that contains tenofovir (such as Atripla, Complera, Stribild, Truvada, or Viread); a beta-blocker-atenolol, bisoprolol, metoprolol, propranolol, sotalol, and others; cholesterol medication such as atorvastatin or rosuvastatin; other antiviral medicines such as efavirenz, ritonavir, or tipranavir; seizure medication-carbamazepine, phenytoin; or tuberculosis medication-rifabutin, rifampin, rifapentine. This list is not complete and many other drugs can interact with sofosbuvir and velpatasvir. This includes prescription and over-the-counter medicines, vitamins, and herbal products. Give a list of all your medicines to any healthcare provider who treats you.
Sofosvel – First generic pan-genotypic Hepatitis C medicine for $840
Two months after Sofosbuvir and Velpatasvir, the world’s first pan-genotypic Hepatitis C medicine, was launched, a Bangladesh-based company has managed to create the first generic version of Sofosbuvir and Velpatasvir. The new medicine known as Sofosvel is a complete copy of the original Sofosbuvir and Velpatasvir with one major difference –Sofosbuvir and Velpatasvir (400mg sofosbuvir/100mg velpastavir) costs $74,760 per treatment; while Sofosvel (400mg sofosbuvir/100mg velpastavir) cost can be as low as $1330 for the same treatment.
Ever since of discovery of antiviral molecule sofosbuvir in late 2013, Hepatitis C is considered a curable disease. A number of drugs such as Sovaldi, Harvoni and Viekira Pak gave doctors the ability to heal Hepatitis C patients with more than 95% success. This rich research activity was championed by the discovery of Sofosbuvir and Velpatasvir – the world’s first medicine that is effective for all Hepatitis C genotypes. Sofosvel is a generic version of Sofosbuvir and Velpatasvir.
Having the ability to cure genotype 1, 2, 3, 4, 5 and 6 patients, Sofosbuvir and Velpatasvir was warmly accepted with one problem; the cost of treatment with Sofosbuvir and Velpatasvir is $74,760. This is lower than existing medicines such as Sovaldi and Harvoni, but a great majority of patients were still unable to cover such great cost of treatment.
This is why Sofosvel is such a savior. Having a Hepatitis C cure that only a few can afford and that is usually not covered by medical insurance is of little use. Sofosvel, created by Beacon Pharma, is essentially a perfect copy of costly Sofosbuvir and Velpatasvir with aconsiderable lower price tag.
Sofosvel price in India, Bangladesh and other countries
The cost of Sofosvel, combined with it’s above 95% cure rate, is the main reason why Hepatitis C patients from all over the world opt to buy generic Sofosbuvir and Velpatasvir instead of the original medicine.
The low price of Sofosvel in India is very important for healing patients who are unable to afford the original. Currently, Sofosvel is being shipped to the US, the UK and European countries, including Russia. Hepatitis C patients reach out to suppliers themselves and Sofosvel suppliers readily help with shipping and handling of the Sofosvel.
The greatest exporter of Sofosvel is India. For all patients in need, here is a quick calculation about how much Sofosvel in India costs:
- Sofosvel standard treatment lasts for 12 weeks with a regimen of 1 pill per day
- Sofosvel is sold in boxes of 6 pills/tablets
- Standard treatment requires 84 pills or 14 boxes
- 1 box of Sofosvel costs $95
In short, for a full treatment a patient needs 14 boxes of Sofosvel, each with a price tag of $102. This means that cost of treatment with Sofosvel is $840. The shipping of Sofosvel from India is charged extra but generally does not cost more than $25.
If you can find a supplier of generic Hepatitis C medicines from India, you should get the necessary medicines at more than $70,000 discount. This is a direct consequence of an open market; for example, the costly US medical system is often being scrutinized. Patients for various kinds of surgeries and specific medicines are traveling to Canada and Europe as well as India to save money on medical services and generic medicines.
Is the import of sofosbuvir/velpatasvir generic pills from India legal?
With Hepatitis C medicines being produced and sold for a fraction of the cost outside the US and EU, the issues of legal import are constantly being raised. In short, can a patient buy Sofosvel in India and bring it back in the US? Can he or she order Sofosver online and have it shipped to the home address?
Dr. James Freeman, a Hepatitis C activist and medical professional, pointed out that goods importation and exportation is covered by the World Trade Organization Agreement. Here is an Article 60 from WTOA that talks about exchange of good for personal use: Article of WTO that allows import of drugs for personal use.
Buying of sofosbuvir/velpatasvir or other generic medications in India and other countries
According to the Article above, ‘small quantities of goods of a non-commerical nature contain in travellers’ personal luggage’ are excluded from restrictions posed by WTOA. 12-weeks worth of generic medicines for Hepatitis C treatment of an individual patient seem to fall in that category. Of course, one must not buy sofosbuvir/velpatasvir medications on bulk and sell them later on.
Looking at it rationally – most of us travel with prescription medicines and would never consider checking them at the airport or report them in any way. Why would Hepatitis C medications be covered any differently?
Buying Sofosvel online, and shipping
Non-commercial goods for individual use can be ‘sent in small consignments’. If you buy Sofosvel online, you would be shipped 14 boxes of medicines which count as ‘small consignment’. On the other hand, one would not think twice about buying online and shipping of goods from eBay, Amazon or Alibaba.
Credible online suppliers of Sofosvel
Finding a credible online supplier of Sofosvel is another matter. Sofosbuvir/velpatasvir pills are sold in the US for about $1,000 per pill. This can be a big incentive for anybody wanting to earn money by selling low-quality and unchecked medications.
The problem with buying medications online is that you cannot be sure if what you’re getting is really 400mg sofosbuvir and 100mg velpatasvir pills. Even if you do later discover the medications were not effective, getting the money back is very difficult. Needless to say, the greatest cost is the time a patient spent taking fake medications.
This is why you have to be sure you are buying from a credible Sofosvel online supplier.
Generic Sofosbuvir and Velpatasvir development – Story of Sofosvel
Here is how the development of generic medicines in the pharmaceutical industry works:
- Originator develops an innovative medicine and holds a patient on it for 20-25 years. The price of medicine is usually very high to cover for research and development, marketing costs, and of course profit.
- After this time generic companies can create perfect duplicates of originator’s medications. Suddenly, there is a generic competition because generic medications are of same quality and effectiveness as originators.
- The price of the medicines drops dramatically, even as much as 90-99% of the originator’s cost.
The case of Sofosbuvir and Velpatasvir is special; the originator allowed some companies to create generic versions of Sofosbuvir and Velpatasvir before the patient’s expiry. This is why the launch of first generic Sofosvel only 2 months after the launch of originator’s Sofosbuvir and Velpatasvir (and not 20-25 years).
This is why the price point fell from $74,760 to $1,330.
Sofosvel, as a generic medicine, must have the same (to a certain point) characteristics as the original Sofosbuvir and Velpatasvir in order to get FDA approval as a generic. The company that created first replicas of sofosbuvir/velpatasvir pills had to show that these pills are the same as the one from the originator’s.
More generic versions of Sofosbuvir and Velpatasvir expected in 2016 and 2017
The originator of Sofosbuvir and Velpatasvir licensed more than 11 companies to create not only sofosbuvir/velpatasvir generics, but sofosbuvir and sofosbuvir/ledipasvir generics as well. Thus far only one company managed to create the Sofosbuvir and Velpatasvir generic; however, all of the companies with the licenses are on their way to launch their own versions.
|Equivalent Brand||Sofosbuvir and Velpatasvir|
|Strength||400mg + 100mg|
|Generic Name||Sofosbuvir & Velpatasvir|
|Manufacturer||Beacon Pharma, BD|
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