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Sofosbuvir is used for:

Treating chronic hepatitis C virus (HCV) infection in certain patients. It must be used with ribavirin or in combination with peginterferon alfa and ribavirin.

Sofosbuvir is an HCV nucleotide analog polymerase inhibitor. It reduces the amount of HCV in the body by preventing the spread of the HCV within the body.

Do NOT use sofosbuvir if:

      • you are allergic to any ingredient in sofosbuvir
      • you are pregnant or may become pregnant
      • your sexual partner is pregnant
      • you are taking carbamazepine, hydantoins (eg, phenytoin), oxcarbazepine, phenobarbital, rifamycins (eg, rifampin), St. John's wort, or tipranavir
      • Contact your doctor or health care provider right away if any of these apply to you.

Before using sofosbuvir:

Some medical conditions may interact with sofosbuvir. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

      • if you are pregnant, planning to become pregnant, or are breast-feeding
      • if you are able to become pregnant
      • if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement
      • if you have allergies to medicines, foods, or other substances
      • if you have liver problems other than HCV (eg, cirrhosis), HIV infection, or anemia
      • if you have kidney problems or you are on dialysis
      • if you have had a liver transplant
      • if you are taking amiodarone. The risk of slow heartbeat may be increased, especially if you are taking a beta blocker (eg, metoprolol), have heart problems, or have severe liver disease

How to use sofosbuvir:

Use sofosbuvir as directed by your doctor. Check the label on the medicine for exact dosing instructions. Check the label on the medicine for exact dosing instructions.

An extra patient leaflet is available with sofosbuvir. Talk to your pharmacist if you have questions about this information.

Sofosbuvir must be taken with either ribavirin or peginterferon alfa and ribavirin, which come with their own Medication Guides. Be sure to read those Medication Guides each time you get them filled.

Take sofosbuvir by mouth with or without food.

Sofosbuvir works best if it is taken at the same time each day.

Continue to take sofosbuvir even if you feel well. Do not miss any doses.

If you miss a dose of sofosbuvir, take it as soon as you remember the same day and go back to your regular dosing schedule. Do not take more than 1 dose of sofosbuvir in the same day. Do not take 2 doses at once.

Ask your health care provider any questions you may have about how to use sofosbuvir.

Important safety information:

Tell your doctor or dentist that you take sofosbuvir before you receive any medical or dental care, emergency care, or surgery.

Sofosbuvir may lower the ability of your body to fight infection. Avoid contact with people who have colds or infections. Tell your doctor if you notice signs of infection like fever, sore throat, rash, or chills.

Sofosbuvir does not stop the spread of HCV to others through blood or sexual contact. Do not have any kind of sex without protection (eg, latex or polyurethane condoms) if you have HCV infection. Do not share needles, injection supplies, or items like toothbrushes or razors. Talk with your health care provider about ways to prevent the spread of HCV to others.

Do not change your dose or stop taking sofosbuvir or any of your medicines without checking with your doctor.

Possible side effects of sofosbuvir:

      • Chills
      • fever
      • lower back or side pain
      • pale skin
      • ulcers, sores, or white spots in the mouth
      • unusual tiredness or weakness
      • Decreased appetite
      • diarrhea
      • difficulty with moving
      • headache
      • irritability
      • lack or loss of strength
      • muscle aching or cramping
      • muscle pains or stiffness
      • nausea
      • rash or itching skin
      • trouble sleeping

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