Nicotine is a stimulant drug that acts as an agonist at nicotinic acetylcholine receptors. These are ionotropic receptors composed up of five homomeric or heteromeric subunits. In the brain, nicotine binds to nicotinic acetylcholine receptors on dopaminergic neurons in the cortico-limbic pathways. This causes the channel to open and allow conductance of multiple cations including sodium, calcium, and potassium. This leads to depolarization, which activates voltage-gated calcium channels and allows more calcium to enter the axon terminal. Calcium stimulates vesicle trafficking towards the plasma membrane and the release of dopamine into the synapse. Dopamine binding to its receptors is responsible the euphoric and addictive properties of nicotine. Nicotine also binds to nicotinic acetylcholine receptors on the chromaffin cells in the adrenal medulla. Binding opens the ion channel allowing influx of sodium, causing depolarization of the cell, which activates voltage-gated calcium channels. Calcium triggers the release of epinephrine from intracellular vesicles into the bloodstream, which causes vasoconstriction, increased blood pressure, increased heart rate, and increased blood sugar.
NuLife should be chewed slowly until a 'peppery' taste appears in the mouth, and then parked between the gum and cheek until the taste fades. Intermittent chewing and parking should continue for 30 minutes. Do not eat or drink 15 minutes before or after chewing.
12-16 chewettes of NuLife per day is recommended for users who smoke 15-30 cigarettes / day during the initial days of therapy, one gum each at equal intervals. This should be tapered down by a quarter each month until the 4th month when complete cessation is achieved. Intermittent use to control craving is recommended to prevent relapse of tobacco dependence.
NuLife is not recommended for patients with gastric ulcers and dentures. Caution must be excercised if symptoms such as jaw fatigue, soreness, gastrointestinal upset (like gaseous distension, hiccups, nausea) occur. Medical intervention will be required for over-dose. Seek medical advise prior to use during pregnancy and lactation.
Nicotine Polacrilex Gum USP
Elder Pharma, India
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Feb 02, 2016
This medication, when used properly, is a life-saver when you are trying to quit smoking! I say "when used properly" because I did not use it properly at first. In addition to Step 1 patch I would also smoke a pack a day - NOT how you want to quit! Once I put down the cigarettes, this patch works! I used the 4mg patches for a week, then went down to Step 2 bc the 1st step caused itching, redness and swelling on my arm. It has now been 2 and 1/2 weeks and I haven't smoked at all! From 20 years of a pack a day to nothing is truly amazing. I am hoping to be free me from the bondage of smoking Good luck on your journey to quit! It is worth it;YOU are worth it!"
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