Lescol (fluvastatin) is in a group of drugs called HMG CoA reductase inhibitors, or "statins." Lescol reduces levels of "bad" cholesterol (low-density lipoprotein, or LDL) and triglycerides in the blood, while increasing levels of "good" cholesterol (high-density lipoprotein, or HDL). Lescol is used to treat high cholesterol in adults and children who are at least 10 years old. Lowering your cholesterol can help prevent heart disease and hardening of the arteries, conditions that can lead to heart attack, stroke, and vascular disease. Lescol may also be used for other purposes not listed in this medication guide.
You should not take Lescol if you are allergic to fluvastatin, if you are pregnant or breast-feeding, or if you have liver disease. Stop taking Lescol and tell your doctor right away if you become pregnant. Before taking Lescol, tell your doctor if you have ever had liver or kidney disease, diabetes, or a thyroid disorder, or if you drink more than 2 alcoholic beverages daily. In rare cases, Lescol can cause a condition that results in the breakdown of skeletal muscle tissue, leading to kidney failure. Call your doctor right away if you have unexplained muscle pain, tenderness, or weakness especially if you also have fever, unusual tiredness, and dark colored urine. Avoid eating foods that are high in fat or cholesterol. Lescol will not be as effective in lowering your cholesterol if you do not follow a cholesterol-lowering diet plan. Avoid drinking alcohol. It can raise triglyceride levels and may increase your risk of liver damage. There are many other drugs that can increase your risk of serious medical problems if you take them together with Lescol. Tell your doctor about all medications you use. This includes prescription, over-the-counter, vitamin, and herbal products. Do not start a new medication without telling your doctor. Keep a list of all your medicines and show it to any healthcare provider who treats you. Lescol is only part of a complete program of treatment that also includes diet, exercise, and weight control. Follow your diet, medication, and exercise routines very closely.
Before taking this medicine
You should not take Lescol if you are allergic to fluvastatin, if you are pregnant or breast-feeding, or if you have liver disease. To make sure you can safely take Lescol, tell your doctor if you have any of these other conditions: history of liver disease; history of kidney disease; diabetes; a thyroid disorder; or if you drink more than 2 alcoholic beverages daily. In rare cases, Lescol can cause a condition that results in the breakdown of skeletal muscle tissue, leading to kidney failure. This condition may be more likely to occur in older adults and in people who have kidney disease or poorly controlled hypothyroidism (underactive thyroid).
Tell your doctor about all other medications you use. Certain other drugs can increase your risk of serious muscle problems, and it is very important that your doctor knows if you are using any of them: erythromycin (E.E.S., EryPed, Ery-Tab, Erythrocin, Pediazole); fluconazole (Diflucan) gemfibrozil (Lopid), fenofibric acid (Fibricor, Trilipix), or fenofibrate (Antara, Fenoglide, Lipofen, Lofibra, Tricor, Triglide); medicines that contain niacin (Advicor, Niaspan, Niacor, Simcor, Slo-Niacin, and others); or drugs that weaken your immune system, such as steroids, cancer medicine, or medicines used to prevent organ transplant rejection, such as cyclosporine (Gengraf, Neoral, Sandimmune), sirolimus (Rapamune), or tacrolimus (Prograf). FDA pregnancy category X. Lescol can harm an unborn baby or cause birth defects. Do not take Lescol if you are pregnant. Stop taking this medication and tell your doctor right away if you become pregnant. Use effective birth control to avoid pregnancy while you are taking Lescol. Fluvastatin may pass into breast milk and could harm a nursing baby. Do not breast-feed while you are taking Lescol.
How should I take Lescol?
Take Lescol exactly as prescribed by your doctor. Do not take in larger or smaller amounts or for longer than recommended. Follow the directions on your prescription label. Lescol is usually taken once or twice daily, with or without food. Take the medicine at the same time each day. Your doctor may occasionally change your dose to make sure you get the best results. Do not crush, chew, break, or open a Lescol tablet or capsule. Swallow it whole. Tell your doctor if you have trouble swallowing the pill. You may need to stop using Lescol for a short time if you have: uncontrolled seizures; an electrolyte imbalance (such as high or low potassium levels in your blood); severely low blood pressure; a severe infection or illness; or surgery or a medical emergency. To be sure Lescol is helping your condition and is not causing harmful effects, your blood will need to be tested often. Visit your doctor regularly. Lescol is only part of a complete program of treatment that also includes diet, exercise, and weight control. Follow your diet, medication, and exercise routines very closely. You may need to take Lescol on a long-term basis for the treatment of high cholesterol. Store at room temperature away from moisture, heat, and light.
What happens if I miss a dose?
Take the missed dose as soon as you remember. Skip the missed dose if your next dose is less than 12 hours away. Do not take extra medicine to make up the missed dose.
What happens if I overdose?
Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.
What should I avoid?
If you also take cholestyramine (Prevalite, Questran) or colestipol (Colestid), avoid taking them within 2 hours before you take Lescol. Avoid eating foods that are high in fat or cholesterol. Lescol will not be as effective in lowering your cholesterol if you do not follow a cholesterol-lowering diet plan. Avoid drinking alcohol. It can raise triglyceride levels and may increase your risk of liver damage.
Lescol side effects
Get emergency medical help if you have any of these signs of an allergic reaction to Lescol: hives; difficulty breathing; swelling of your face, lips, tongue, or throat. Stop taking Lescol and call your doctor at once if you have any of these serious side effects: unexplained muscle pain, tenderness, or weakness; confusion, memory problems; fever, unusual tiredness, and dark colored urine; pain or burning when you urinate; swelling, weight gain, urinating less than usual or not at all; increased thirst, increased urination, hunger, dry mouth, fruity breath odor, drowsiness, dry skin, blurred vision, weight loss); or nausea, upper stomach pain, itching, loss of appetite, dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes). Less serious Lescol side effects may include: headache; mild muscle pain; diarrhea; mild nausea; stomach pain or indigestion; sleep problems (insomnia); or cold symptoms such as stuffy nose, sneezing, sore throat.
What other drugs will affect Lescol?
Before taking Lescol, tell your doctor about all other medicines you are using, especially: cimetidine (Tagamet); a blood thinner such as warfarin (Coumadin, Jantoven); glyburide (DiaBeta, Glynase, Micronase); omeprazole (Prilosec); phenytoin (Dilantin); ranitidine (Zantac); spironolactone (Aldactone, Aldactazide); or any other "statin" medication such as atorvastatin (Lipitor, Caduet), lovastatin (Altoprev, Mevacor), pravastatin (Pravachol), rosuvastatin (Crestor), or simvastatin (Zo cor, Simcor, Vytorin). This list is not complete and other drugs may interact with Lescol. Tell your doctor about all medications you use. This includes prescription, over-the-counter, vitamin, and herbal products. Do not start a new medication without telling your doctor.
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Feb 03, 2016
Lescol lowered my LDL cholesterol from 270 to 101, but my HDL remains at only 36. I am a 63 year old male . My doctor recently prescribed Simcor, a combination of Zocor and Niacin 500/20 , to try and raise the HDL. During tests over the last 8 years on Lescol my HDL has been anywhere from the present 36 to 40. My liver enzymes have been slightly high, but evidently not enough to concern my doctor. I have no muscle pain or weakness, but am also on blood pressure medicines, which make me feel tired and lethargic. Since I have depleted the types of BP medicines, I assume I will just have to live with it. Exercise helps this tiredness, but a bad back and nerves in my lower back and hip prevent much exercise."
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