Ledifos (Ledipasvir 90mg and sofosbuvir 400mg)
Ledifos (Ledipasvir and sofosbuvir) is used for
Treating chronic hepatitis C virus (HCV) infection in certain patients.
Ledipasvir and sofosbuvir is a combination of 2 hepatitis C virus (HCV) antiviral agents. It reduces the amount of HCV in the body by preventing the spread of the HCV within the body.
How to use Ledifos (ledipasvir and sofosbuvir)
Use ledipasvir and sofosbuvir as directed by your doctor. Check the label on the medicine for exact dosing instructions. Check the label on the medicine for exact dosing instructions.
- An extra patient leaflet is available with ledipasvir and sofosbuvir. Talk to your pharmacist if you have questions about this information.
- Take ledipasvir and sofosbuvir by mouth with or without food.
- Do not take an antacid that has aluminum or magnesium in it within 4 hours of ledipasvir and sofosbuvir.
- If you take cimetidine, dexlansoprazole, esomeprazole, famotidine, lansoprazole, nizatidine, omeprazole, pantoprazole, rabeprazole, or ranitidine, ask your doctor or pharmacist how to take it with ledipasvir and sofosbuvir.
- Ledipasvir and sofosbuvir works best if it is taken at the same time each day.
- Continue to take ledipasvir and sofosbuvir even if you feel well. Do not miss any doses.
- If you miss a dose of ledipasvir and sofosbuvir, take it as soon as you remember the same day and go back to your regular dosing schedule. Do not take more than 1 dose of ledipasvir and sofosbuvir in the same day. Do not take 2 doses at once.
Ask your health care provider any questions you may have about how to use ledipasvir and sofosbuvir.
What is the best price of Ledifos tablets?
Only SafeGenericPharmacy can offer at Only @$511 for Ledifos 28 tablets price in india
We take guarantee of quality and delivery anywhere in the world as per the buyer’s requirements.
Where can i buy Ledifos tablets?
SaefGenericPharmacy who can ship Ledifos tablets (cancer treatment medicines) to any country of the world as per the buyer's requirement and government regulations of the country. Ledifos is manufactured by Hetero Pharma Ltd
SaefGenericPharmacy provides options of choosing exporter and supplier of cancer treatment medicines we take guarantee of quality and delivery anywhere in the world as per the buyer’s requirements.
Is Ledifos tablets available in india?
Ledifos tablets is a (prescription drug, prescription medication or prescription medicine) pharmaceutical drug that legally requires a medical prescription to be dispensed.
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Ledifos tablets can be made available mumbai, kolkata, hyderabad, chennai, ahmedabad, delhi, bangalore and pune and other cities in india"
SaefGenericPharmacy can facilitate the supply of Ledifos tablets (prescription medicines) to all locations in the world and in india after fulfilling the legal requirement (if applicable)
How order will be confirmed ?
The order will be confirmed only after the receipt of
Valid prescription of clinician
Import permit if applicable
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Cost of Ledifos tablets in australia, brazil, china, canada, eqypt, europe, france, germany, hongkong, india, iran, italy, mexico, pakistan, poland, spain, singapore, thailand, russia, romania, uk, middle east, uae, ukraine.
Ledifos tablets is a formulation combination of anti-viral medications ledipasvir and sofosbuvir used in the treatment of chronic hepatitis c virus (chcv) infection genotype 1. Ledifos is a prescription medicine containing ledipasvir (90mg) a viral ns5a inhibitor and sofosbuvir (400mg) a nucleotide inhibitor of the viral rna polymerase.
The international brand name of this medicine is harvoni that provides effective treatment in hepatitis c genotype 1 with a cure rate ranging between 94% to 99%. Ledifos helps prevent hepatitis c virus infection from multiplying in your body by weakening the virus and inhibiting its reproduction and replication.
Colours: ferric oxide (yellow) usp/f & titanium dioxide usp
Dosage & administration
Ledifos is to be administered under the strict supervision of a hepatologist only.
Ledifos is to be taken by adults over 18 years of age only.
Ledifos is to be taken orally with a full glass of water.
the maximum recommended dosing frequency is once per day.
to be taken at the same time every day (24 hour gap).
Ledifos's length of treatment may vary for a period between 8 weeks to 24 weeks.
do not stop use and intake of other anti-viral medications alongside hepcinat unless instructed by your doctor.
Important - the correct dosage and prescription commonly depend on the patient and the condition being treated. Duration of dosage can range between 8 weeks to 24 weeks and the correct duration of treatment is to be determined by your medical practitioner or doctor as it will depend on the patient's condition and their response to the therapy. Do not adjust your dosage without the approval of your medical practitioner or doctor. This product is only for use as prescribed and instructed by a doctor or medical practitioner.
Ledifos's active ingredients are ledipasvir & sofosbuvir which may have reported side effects as under:
common side effects / symptoms - consult your doctor or medical practitioner if you experience any common side effects or symptoms such as nausea, diarrhea, headache, loss of appetite, lower back pain, side pain, insomnia (sleeplessness) and/or fever.
serious side effects / symptoms - discontinue use of Ledifos and contact your emergency medical centre right away if you experience any signs of pale skin, hives, rashes, edema (swelling), mood changes, excessive fatigue, behaviour changes, irregular heartbeat, breathing difficulty, breathlessness, swallowing difficulty and/or signs of any infection.
unknown side effects / symptoms: Ledifos may cause other unknown side effects or symptoms not listed here. For complete information, discuss the use of hepciant-lp with your doctor or healthcare medical practitioner before use.
Contradictions & warnings
Ledifos is not always suitable for all patients. Do not take Ledifos as it is contradicted in the following known cases:
pregnancy / breast feeding - do not use Ledifos if you are pregnant or breastfeeding or trying to get pregnant.
unprotected sex - Ledifos is contradicted for use during unprotected sexual intercourse as it may also lead to birth defects.
antacids - Ledifos is not to be taken within a before and after 4 hour period of taking any antacids.
sofosbuvir / ledipasvir medications - do not take Ledifos when taking other medications having sofosbuvir and/or ledipasvir as their active ingredients. Ledifos is also contradicted when taken alongside other medications used in the treatment of hepatitis c virus (hcv) infection.
sofosbuvir / ledipasvir allergy - Ledifos is contradicted for use if you are allergic to sofosbuvir and/or ledipasvir which are the active ingredients of Ledifos.
other herbal / dietary supplements / prescription medicines / otc medicines - Ledifos may be contradicted for use when taken with other medications to treat tuberculosis, seizures, hiv, cancer, cholesterol, heart ailments and other anti-viral medications. Consult your medical practitioner or doctor before using Ledifos by providing a list of any and all existing medications that you are taking to ascertain the safety and use of Ledifos.
hepatitis c is a viral infection that causes inflammation of the liver. Genotypes are used to identify particular strains of hcv which are based upon differences in particular regions of the viral genome. Harvoni (gilead sciences, inc.) Is a prescription medicine which contains a combination of sofosbuvir and ledipasvir in the dosages form of 90mg and 400 mg that is used for treatment of chronic hepatitis c (chc) genotype 1 infection in adults. It is not recognized yet if harvoni is safe and effective medicine for children under 18 years of age.
Genotype 1 hcv is the most common infection accounting for 70 to 75% of the entirely hepatitis c infections in the united states. Ledipasvir and sofosbuvir are antiviral medications that help to prevent hepatitis c virus (hcv) cells from multiplying in your body.
The indian generic of harvoni to be manufactured by Hetero pharma limited is available now in india under the trade name Ledifos. This drug also have similar effects as harvoni in treating chronic hepatitis c (chc) genotype 1 infection in adults. The recommended dosage of Ledifos is one tablet taken orally once daily with or without food.
8 weeks:this treatment can be considered for naive patients without cirrhosis who have pre-treatment hcv rna < 6 million iu/ml
12 weeks:for naive patients with or without cirrhosis
12 weeks:for experienced patients without cirrhosis those have failed treatment with either peginterferon alfa + ribavirin or an hcv protease inhibitor + peginterferon alfa + ribavirin.
24 weeks:for experienced patients with cirrhosis who have failed treatment with either peginterferon alfa + ribavirin or an hcv protease inhibitor + peginterferon alfa + ribavirin
harvoni (ledipasvir 90mg & sofosbuvir 400mg) - ledipasvir inhibits ns5a, an important phosphoprotein, which is involved in viral replication, assembly and secretion. Resistance selection in cell culture and cross-resistance studies indicates ledipasvir aims ns5a as its mode of action.
Sofosbuvir is an inhibitor of the hcv ns5b - the key enzyme mediating hcv rna replication. Virus needs rna molecule to reproduce, and sofosbuvir prevents this rna molecule from forming.
Ledipasvir & sofosbuvir work synergetically to weaken hepatitis c replication. In such a way, virus is weakened. Immune system does the rest.
the most common adverse reactions were fatigue and headache in subjects treated with 8, 12, or 24 weeks of harvoni. Other possible adverse reactions could be nausea, diarrhoea and insomnia.
Note: the patient should not take any antacid 4 hours prior or 4 hours after taking the drug. The patient should be more careful in case the antacids contain magnesium or aluminium. If there is any allergic reaction or any sign of reaction to harvoni like difficulty in breathing or swelling of the tongue, lips, face or throat; it is recommended to consult the specialist concerned immediately. Please tell your healthcare provider or contact your treating doctor directly if you found any side effect that bothers you or that does not go away.
Ledifos comes in the category of prescription drugs that is also categorized in the list of prescription medicines but in order to dispense this particular drug, there is a legal requirement of a medical prescription. The drug can be made available in all the major cities of india. The confirmation of the order of this particular drug will be made after the valid prescription from hepatologist or hcv treatment specialist.
Our commitment: our objectives is to help people suffering from hepatitis c and other serious life threatening diseases across the world in procuring indian medicines which are trusted by doctors, medical practitioners and other institutions all around the world and are available at cheap and competitive prices.
SaefGenericPharmacy like to assure you of the best of the quality of medicines and services in the industry. Ledifos, the generic version of harvoni, is now available in india at affordable price. We are available for our clients round the clock and can also be reached on whatsapp, qq, viber, line and other online social apps on the internet.
Harvoni cost in usa, canada, europe, egypt, india and more
Harvoni is the most effective hepatitis c treatment known to man. Here are the cost of standard 12-week treatment around the world:
us – $94,5000
canada – $84,000
uk – £39,000
france – 48,000€
egypt – $12,000
india – $1511
germany – 41,000€
We have secured a partnership with a trusted and certified generic sovaldi and harvoni seller and can offer 3-bottles worth of hepatitis c medications for a 99% percent lower prices than original us price. We reveal how to get in touch with our partner via the manual – you can read more about the manual below.
Us price is $94,500 per treatment, in india generic harvoni is only $1511. Price in europe is 41,000€ (france). Where to buy cheapest harvoni in the us? Unfortunately, harvoni cost in the usa and other countries around the world is also one of the highest of any drug treatments available. When the cost of sovaldi pill, harvoni’s predecessor, was $1000 per pill and more than $50,000 per treatment, people and insurance agencies alike have questions if the price for the sofosbuvir drug is justifiable. When gilead sciences introduced an upgraded drug harvoni on the market, the effectiveness was not questioned, the main issue was the harvoni cost on us market, and what cost of harvoni pills can other countries in europe and asia expect. Harvoni price in the usa was set to $94,500 per 12-week treatment. How much harvoni costs around the world? In india only $1511 per 12-week treatment. In collaboration with hepatitis c society, we have prepared a manual of how to get generic harvoni shipped from india.
Harvoni is nothing short than a wonder drug for hepatitis c patients. Treatment before sovaldi and harvoni were available was unsuccessful in more than 50% of cases making hepatitis c virus a deadly disease. Treatment included daily injections of interferon that causes headaches and unwanted immune responses. Because of this pharmaceutical industry unloaded billions of dollars into research and development of new hepatitis c drug. The result is molecule called sofosbuvir, out of which sovaldi and harvoni are made out of. Sovaldi pills consist of 400 mg of sofosbuvir (price tag around $1000), harvoni consists of sofosbuvir and an additional substance ledipasvir (price tag for sofosbuvir-ledipasvir 400mg/90mg pill is around $1,125). The cost of harvoni is sometimes justified by the lack of alternative treatments and the cost of a new liver – app. $250,000 – which is needed for hepatitis c patients if everything else fails.
The fruit of gilead research was a tremendous success. And because created billions of costs in research and is a very effective drug, the harvoni cost can be justified to be so high. There are many discussions if the cost of harvoni is too high but if you are in need of it and the alternative is certain death, then the price tag doesn’t matter that much. However, in some countries around the world cheaper versions of harvoni can be bought. Where can i buy cheap harvoni?
How to get generic harvoni or generic sovaldi from india
Original harvoni and sovaldi made by gilead sciences is being sold in the developed world for a very high price. Current price of original harvoni in us is $94,500 per 12-week treatment and more than 50,000€ in many european countries. This is why, for example, harvoni is currently the second best selling drug in the world (2014 sales: $10.3 billion). However, gilead is known for giving licences to pharmaceutical companies in developing world such as india and egypt to create generic version of their drugs at much lower prices. In case of the new hepatitis c treatments, generic harvoni as well as generic sovaldi are being manufactured in 7 pharmaceutical plants in india and it is primarily meant to help indian population by curing them of hepatitis c. Because generic harvoni treatment is being sold for as low as $1,000 per 12-week treatment as oppose to staggering prices in the developed world, more and more people are looking to save more than $90,000 by buying generic harvoni from india.
Luckily there is a way of how to buy generic harvoni from india and the purpose of this article is to roughly outline how does one go about buying generic harvoni from india. If you’re interested in acomplete step-by-step manual of how to buy generic harvoni for around $1,000 you can buy it below.
Why can india produce and sell generic harvoni
Usually a drug such as harvoni is patented and the originator (in this case gilead sciences) has an exclusivity on producing and selling the drug. However, even when sovaldi came out in december 2013 in us, india had problems with paying such a high price for life saving disease. Because india is such a big market with more than 1 billion people and estimated more than 30 million hepatitis c patients, gilead sciences had agreed to give licences to 7 india’s pharmaceutical plants to produce and sell generic harvoni and generic sovaldi at a very low cost. On every sale, however, gilead sciences profits from royalties. Given that generic harvoni is sold for around 5$ per pill if gilead reaps $1 royalties there is still around $250 billion to be made in india alone on hepatitis c.
In negotiations for this deal from which now every us or european hepatitis c patient can benefit it was stated by indian authorities that they don’t recognize the innovation that went into developing of harvoni’s active ingredient sofosbuvir. Because the molecule is very similar to other antiviral drugs that already exist in the market, gilead went on to give licences to produce generic sovaldi at first, and when harvoni came out in us the licence to produce generic harvoni followed.
How does the system for buying generic drugs work in india
In order to understand how one can buy generic harvoni from india it is important to understand what kind of system india has for buying generic drugs. There are three factors:
Drug production (limited to 7 companies having licences from gilead sciences to produce generic harvoni)
Drug distributers (wholesale companies registered to sell generic drugs to pharmacies and individuals)
Pharmacies (taking care of general distibution and dispension of generic harvoni)
Who can produce generic harvoni in india
Among the 7 companies licences to produce new hepatitis c drugs the most important onces are mylan and Hetero pharma. Mylan launched a generic sovaldi under trademark name myhep – these are 400 mg sofosbuvir pills without 90 mg ledipasvir which is present in harvoni. Hetero pharma, on the other hand, had launched both generic sovaldi under the name Sofovir and generic harvoni under the name Ledifos and are selling it in more than 100 developing countries (for example price for 28-pill bottle in nepal is around $380).
Hetero pharma generic harvoni sold under trademark Ledifos
Other companies that can produce generic harvoniare cipla, hetero labs, ranbaxy laboratories, sequent scientific and strides arcolab.
How can anyone buy generic harvoni in india
If you are us or european citizen in need of harvoni for hepatitis c treatment you might have a problem with buying original harvoni because of the very high costs. This is why ‘hepatitis c turism’ is starting to flourish in india because more and more people are going to india to try to procure generic harvoni costing only around $1,000. The major problem is how to actually buy it either by going to india or doing it online with a reputable online pharmacy. This is also the reason why we started to work on the manual of how to buy generic harvoni by making a step-by-step instructions for all patients in need of new hepatitis c drugs. Here are some questions that are fully explained in the manual.
I have a prescription for harvoni by us doctor but i can’t afford the costs. Can i just go with it to india and buy generic harvoni?
Getting generic harvoni is unfortunately as simple as flying to india, going to the first pharmacy and getting generic harvoni with non-indian prescription. Patients are advised to know beforehand what they need with them and who to contact.
Indian prescription by indian doctor
The us or european prescription is not valid in other countries such as india. In order to buy generic harvoni one must make an appointment with indian doctor – we enlist specialist who are allowed to write a hepatitis c patient a prescription for either generic harvoni or generic sovaldi.
In order for a doctor to be able to prescribe hepatitis c drugs he or she must confirm the diagnosis of hepatitis c. This includes a series of blood test that need to be performed as well fibroscan.
Here is a little scoop from the manual – the paperwork indian doctors have to fill out in order to write generic hepatitis c prescription includes specific tests that need to be made in order to confirm hepatitis c virus presence in a patient. Here is a tip: most of the indian doctors will accept test results from us, europe, egypt, canada and alike. Bringing all results and blood work you had done with your current doctor to india will not only save you some money but you will avoid the delay that getting appointments for tests and waiting for results might cause.
Additionally, be careful that you get a prescription for generic harvoni from the above stated companies with licences which are approved by fda. Mylan‘s myhep and Hetero’s Ledifos are reputable and credible medicines. In order to avoid having problems with getting prescription for non-credible drugs we have included a list of doctors and trademark hepatitis c generics in the manual.
|Strength||90mg + 400mg|
|Generic Name||Ledipasvir & Sofosbuvir|
|Manufacturer||Hetero Pharma, India|
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