Folic acid (also known as vitamin B9 or folacin) and folate (the naturally occurring form), as well as pteroyl-L-glutamic acid and pteroyl-L-glutamate, are forms of the water-soluble vitamin B9. Folic acid is itself not biologically active with its biological importance being due to tetrahydrofolate and other derivatives after its conversion to dihydrofolic acid in the liver.
Vitamin B9 (folic acid and folate inclusive) is essential to numerous bodily functions ranging from nucleotide biosynthesis to the remethylation of homocysteine. The human body needs folate to synthesize DNA, repair DNA, and methylate DNA as well as to act as a cofactor in biological reactions involving folate. It is especially important during periods of rapid cell division and growth. Both children and adults require folic acid to produce healthy red blood cells and prevent anemia. Folate and folic acid derive their names from the Latin word folium (which means "leaf"). Leafy vegetables are a principal source, although in Western diets fortified cereals and bread may be a larger dietary source.
A lack of dietary folic acid leads to folate deficiency (FD). This can result in many health problems, most notably neural tube defects in developing embryos. Low folate can also lead to homocysteine accumulation as a result of one carbon metabolism mechanism being impaired. DNA synthesis and repair are impaired and this could lead to cancer development. Supplementation in the general population may however lead to increased rates of cancer and all-cause mortality.
Other Drug Interactions
Antiepileptics, oral contraceptives, anti- TB drugs, alcohol, aminopterin, methtrexate, pyrimethamine, trimethoprim & sulphonamides may result to decrease in serum folate contractions. Decreases serum phenytoin concentrations.
Undiagnosed megaloblastic anaemia; pernicious, aplastic or normocytic anaemias.
GI Irritation, Epigastric Pain, Stomach Cramping, Constipation, Nausea, Vomiting, Diarrhoea, Dark Stools, Heart Burn, Discoloured Urine, Teeth Staining. IM: Pain At Inj Site, Abdominal Pain At Lower Quadrant And Local Inflammation With Inguinal Lymphadenopathy. IV: Joint And Muscle Pain, Bronchospasm, Hypotension, Tachycardia, Flushing, Sweating, Dizziness. Potentially Fatal: Parenteral: Anaphylactoid Reactions, Circulatory Collapse.
Hypersensitivity Or Intolerance To Iron And Overloading Of Iron In The Body. Anaemia Not Caused By Iron Deficiency. Disturbances In Iron Utilisation, Thalassemia. Patients Receiving Repeated Blood Transfusion. Parenteral: Iron Overload, Ostler-Rendu-Weber Syndrome, Chronic Polyarthritis, Bronchial Asthma, Inflammation Or Infection Of Kidney Or Liver, Uncontrolled Hyperparathyroidism, Decompensated Liver Cirrhosis. Pregnancy (1st Trimester).
Mechanism of Action:
Iron Polymaltose Is A Water Soluble, Macro-Molecular Complex Of Iron (III) Hydroxide And Isomaltose. It Is Used In The Treatment Of Iron-Deficiency Anaemia.
Avoid Concomitant Parenteral And Oral Iron Admin, Oral Iron Therapy Should Start At Least 1 Wk After Last Iron Inj. Parenteral: Pregnancy (2nd And 3rd Trimester), Allergies, Hepatic And Liver Insufficiency, Low Iron Binding Capacity And Or Folic Acid Deficiency. Facilities For CPR Should Be Available During Admin. Excessive IV Infusion Rate May Cause Nausea And Epigastric Upset. IV Infusion Route Should Be Used Only If IM Route Is Unacceptable And When There Is No Stored Iron In The Bone Marrow.
100 + 350mg
Iron folic Acid
Emcure Pharma, India
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