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estradiol 

What is estradiol?

Estradiol is a form of estrogen, a female sex hormone produced by the ovaries. Estrogen is necessary for many processes in the body.

Estradiol is used to treat symptoms of menopause such as hot flashes, and vaginal dryness, burning, and irritation. Other uses include prevention of osteoporosis in postmenopausal women, and replacement of estrogen in women with ovarian failure or other conditions that cause a lack of natural estrogen in the body.

Estradiol is sometimes used as part of cancer treatment in women and men.

important information

You should not use estradiol if you have: liver disease, a bleeding disorder, unusual vaginal bleeding, history of a hormone-dependent cancer (such as breast, uterine, ovarian, or thyroid cancer), or if you have ever had a heart attack, stroke, or a blood clot.

Do not use if you are pregnant.

Estradiol may increase your risk of developing a condition that may lead to uterine cancer. Call your doctor at once if you have any unusual vaginal bleeding while using this medicine.

Estradiol should not be used to prevent heart disease, stroke, or dementia, because this medicine may actually increase your risk of developing these conditions. Long-term use may also increase your risk of breast cancer or blood clot.

Estradiol can harm an unborn baby or cause birth defects. Do not use estradiol if you are pregnant. You should not take estradiol if you have abnormal vaginal bleeding, liver disease, breast or uterine cancer, hormone-dependent cancer, a recent history of heart attack or stroke, if you are pregnant, if you have ever had a blood clot (especially in your lung or your lower body), or if you are allergic to any medicines or food dyes. Taking hormones can increase your risk of blood clots, stroke, or heart attack, especially if you have diabetes, high blood pressure, high cholesterol or triglycerides, if you smoke, or if you are overweight.

Have regular physical exams and mammograms, and self-examine your breasts for lumps on a monthly basis while using estradiol.

Before taking this medicine

You should not use this medicine if you are allergic to estradiol, if you are pregnant, or if you have:

    • unusual vaginal bleeding that a doctor has not checked;
    • liver disease;
    • a bleeding or blood-clotting disorder;
    • a recent history of heart attack or stroke;
    • a history of hormone-dependent cancer (such as breast, uterine, ovarian, or thyroid cancer);
    • if you have ever had a blood clot (especially in your lung or your lower body); or
    • if you are allergic to any medicines or food dyes.
    • Estradiol should not be used to prevent heart disease, stroke, or dementia, because this medicine may actually increase your risk of developing these conditions.

To make sure estradiol is safe for you, tell your doctor if you have:

    • heart disease;

risk factors for coronary artery disease (such as diabetes, lupus, smoking, being overweight, having high blood pressure or high cholesterol, having a family history of coronary artery disease);

    • a history of jaundice caused by pregnancy or birth control pills;
    • a thyroid disorder;
    • kidney disease;
    • asthma;
    • epilepsy or other seizure disorder;
    • migraines;
    • porphyria (a genetic enzyme disorder that causes symptoms affecting the skin or nervous system);
    • endometriosis or uterine fibroid tumors;
    • gallbladder disease;
    • high or low levels of calcium in your blood; or
    • if you have had your uterus removed (hysterectomy).
    • Long-term use of estradiol may increase your risk of breast cancer, heart attack, stroke, or blood clot. Talk with your doctor about your individual risks before using estradiol long term.
    • Do not use estradiol if you are pregnant. Tell your doctor right away if you become pregnant during treatment. Use effective birth control while you are using this medicine.
    • Estradiol can pass into breast milk. This medication may slow breast milk production. Tell your doctor if you are breast-feeding a baby.

How should I take estradiol?

Take estradiol exactly as it was prescribed for you. Follow all directions on your prescription label. Do not take this medicine in larger or smaller amounts or for longer than recommended.

Estradiol may increase your risk of developing a condition that may lead to uterine cancer. Your doctor may prescribe a progestin to take while you are using estradiol, to help lower this risk. Report any unusual vaginal bleeding right away.

Your doctor should check your progress on a regular basis (every 3 to 6 months) to determine whether you should continue this treatment. Self-examine your breasts for lumps on a monthly basis, and have regular mammograms while using estradiol.

If you need surgery or medical tests or if you will be on bed rest, you may need to stop using this medicine for a short time. Any doctor or surgeon who treats you should know that you are using estradiol.

Store at room temperature away from moisture, heat, and light. Keep the bottle tightly closed when not in use.

How should I take estradiol?

Take estradiol exactly as it was prescribed for you. Follow all directions on your prescription label. Do not take this medicine in larger or smaller amounts or for longer than recommended.

Estradiol may increase your risk of developing a condition that may lead to uterine cancer. Your doctor may prescribe a progestin to take while you are using estradiol, to help lower this risk. Report any unusual vaginal bleeding right away.

Your doctor should check your progress on a regular basis (every 3 to 6 months) to determine whether you should continue this treatment. Self-examine your breasts for lumps on a monthly basis, and have regular mammograms while using estradiol.

If you need surgery or medical tests or if you will be on bed rest, you may need to stop using this medicine for a short time. Any doctor or surgeon who treats you should know that you are using estradiol.

Store at room temperature away from moisture, heat, and light. Keep the bottle tightly closed when not in use.

What happens if I miss a dose?

Take the missed dose as soon as you remember. Skip the missed dose if it is almost time for your next scheduled dose. Do not take extra medicine to make up the missed dose.

Estradiol side effects

Get emergency medical help if you have any of these signs of an allergic reaction to estradiol: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Call your doctor at once if you have:

heart attack symptoms - chest pain or pressure, pain spreading to your jaw or shoulder, nausea, sweating;

signs of a stroke - sudden numbness or weakness (especially on one side of the body), sudden severe headache, slurred speech, problems with vision or balance;

signs of a blood clot in the lung - chest pain, sudden cough, wheezing, rapid breathing, coughing up blood;

signs of a blood clot in your leg - pain, swelling, warmth, or redness in one or both legs;

swelling or tenderness in your stomach;

jaundice (yellowing of the skin or eyes);

unusual vaginal bleeding;

a lump in your breast;

fluid retention (swelling, rapid weight gain); or

high levels of calcium in your blood - nausea, vomiting, stomach pain, loss of appetite, constipation, increased thirst or urination, muscle pain or weakness, joint pain, confusion, and feeling tired or restless.

Common estradiol side effects may include:

breast pain;

headache;

vaginal itching or discharge, changes in your menstrual periods, light vaginal bleeding or spotting;

thinning scalp hair; or

nausea, vomiting, bloating, stomach cramps.

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