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Estrace

What is Estrace?

Estrace tablets contains estradiol, a form of estrogen. Estradiol is a female sex hormone produced by the ovaries that regulates many processes in the body.

Estrace is used to treat symptoms of menopause such as hot flashes, and vaginal dryness, burning, and irritation. Other uses include prevention of osteoporosis in postmenopausal women, and replacement of estrogen in women with ovarian failure or other conditions that cause a lack of natural estrogen in the body.Estrace is sometimes used as part of cancer treatment in women and men.

Important information

You should not use Estrace if you have: liver disease, a bleeding disorder, unusual vaginal bleeding, history of a hormone-dependent cancer (such as breast, uterine, ovarian, or thyroid cancer), or if you have ever had a heart attack, stroke, or a blood clot.

Before taking this medicine

You should not use Estrace if you are allergic to estradiol, if you are pregnant, or if you have:

    • unusual vaginal bleeding that a doctor has not checked
    • liver disease
    • a bleeding or blood-clotting disorder
    • a recent history of heart attack or stroke
    • a history of hormone-dependent cancer (such as breast, uterine, ovarian, orthyroid cancer)
    • if you have ever had a blood clot (especially in your lung or your lower body)
    • if you are allergic to any medicines or food dyes.

Estrace should not be used to prevent heart disease, stroke, or dementia, because this medicine may actually increase your risk of developing these conditions

To make sure Estrace is safe for you, tell your doctor if you have:

    • heart disease
    • risk factors for coronary artery disease (such as diabetes, lupus, smoking, being overweight, having high blood pressure or high cholesterol, having a family history of coronary artery disease)
    • a history of jaundice caused by pregnancy or birth control pills
    • a thyroid disorder
    • kidney disease
    • asthma
    • epilepsy or other seizure disorder
    • migraines
    • porphyria (a genetic enzyme disorder that causes symptoms affecting the skin or nervous system)
    • endometriosis or uterine fibroid tumors
    • gallbladder disease
    • high or low levels of calcium in your blood
    • if you have had your uterus removed (hysterectomy).

Long-term use of Estrace may increase your risk of breast cancer, heart attack, stroke, or blood clot. Talk with your doctor about your individual risks before using Estrace long term.

Do not use Estrace if you are pregnant. Tell your doctor right away if you become pregnant during treatment. Use effective birth control while you are using this medicine.

Estradiol can pass into breast milk. Estrace may slow breast milk production. Tell your doctor if you are breast-feeding a baby.

How should I take Estrace?

Take Estrace exactly as it was prescribed for you. Follow all directions on your prescription label. Do not take this medicine in larger or smaller amounts or for longer than recommended.

Estrace may increase your risk of developing a condition that may lead to uterine cancer. Your doctor may prescribe a progestin to take while you are using this medicine, to help lower this risk. Report any unusual vaginal bleeding right away.

Your doctor should check your progress on a regular basis (every 3 to 6 months) to determine whether you should continue this treatment. Self-examine your breasts for lumps on a monthly basis, and have regular mammograms while taking Estrace.

If you need surgery or medical tests or if you will be on bed rest, you may need to stop using this medicine for a short time. Any doctor or surgeon who treats you should know that you are using Estrace.

Store at room temperature away from moisture, heat, and light. Keep the bottle tightly closed when not in use.

Major Side Effects

You should check with your doctor immediately if any of these side effects occur when taking estradiol:

Less common:

    • Vaginal yeast infection
    • Incidence not known:
    • Change in vaginal discharge
    • clear or bloody discharge from the nipple
    • decrease in the amount of urine
    • dimpling of the breast skin
    • fast heartbeat
    • fever
    • hives, itching, or rash
    • hoarseness
    • inverted nipple
    • irritation
    • joint pain, stiffness, or swelling
    • lump in the breast or under the arm
    • noisy, rattling breathing
    • pain or feeling of pressure in the pelvis
    • pain, redness, or swelling in the arm or leg
    • persistent crusting or scaling of the nipple
    • redness of the skin
    • redness or swelling of the breast
    • sore on the skin of the breast that does not heal
    • swelling of the eyelids, face, fingers, lips, hands, feet, or lower legs
    • tightness in the chest
    • troubled breathing at rest
    • troubled breathing or swallowing
    • vaginal bleeding

If any of the following symptoms of overdose occur while taking estradiol, get emergency help immediately:

Symptoms of overdose:

    • Abdominal or stomach pain
    • dizziness
    • drowsiness
    • nausea or vomiting
    • tenderness of the breasts
    • unusual tiredness or weakness

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